Cottonwood Slough-Dry Run is a glacial wetland adjacent to Lake Kampeska in Roberts County, South Dakota, United States. The complex is located near Watertown in eastern South Dakota. Owned by the State of South Dakota and the private sector, the wetland was listed as a National Natural Landmark in 1975.

Description The National Park Service describes Cottonwood Slough-Dry Run as follows:

Pleistocene glaciers created a morphologically diverse wetland formation. A wide variety of plants and animals can live within the 6,424-acre wetland parcel that has been granted Landmark designation.

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