Mathebula is a South African surname. Notable people with the surname include:
David Mathebula (born 1983), South African soccer player Elphus Mathebula, South African politician Jeffrey Mathebula (born 1979), South African boxer Peter Mathebula (1952–2020), South African boxer Tweezy (born Tumelo Thandokuhle Mathebula; 1992), South African rapper and producer