Lepani is a surname, commonly used in Papua New Guinea. Notable people with the surname include:
Andrew Lepani (born 1979), Papua New Guinean footballer Charles Lepani (1947–2025), Papua New Guinean public servant and diplomat Nathaniel Lepani (born 1982), Papua New Guinean footballer
See also Lepani Nabuliwaqa (born 1980), Fijian rugby union footballer