Manuel Pérez de Guzmán may refer to: Manuel Pérez de Guzmán (landowner) (1863–1920), Spanish landowner and sportsperson Manuel Pérez de Guzmán, 12th Duke of Medina Sidonia (1671–1721), Spanish nobleman Manuel Pérez de Guzmán y Boza (1852–1929), Spanish bibliophile and politician Manuel Pérez de Guzmán (footballer) (1888–1957), Spanish footballer Manuel de Guzmán y Silva, 8th Duke of Medina Sidonia (1579–1636), Spanish noble