Amotriphene is a coronary vasodilator that was developed at Sterling Drug in the early 1960s.Elpern Bill, & (1961 & 1964 both to Sterling Drug Inc). It has selective binding to alpha-adrenergic receptors.
As a triphenylethylene, it has a structure similar to chlorotrianisene, although it is not thought to function as a non-steroidal synthetic estrogen.
Its pharmacology has been studied.
Synthesis The literature procedure that was published involved Mannich reaction to desoxyanisoin followed by organometallic addition of anisyl magnesium bromide and dehydration of the resulting alcohol.
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