Mcn 5707 is a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) designated for the treatment of depression. It was developed by Bruce Maryanoff of McNeil (now Johnson & Johnson) in the 1980s.
Binding affinities Binding affinities (Ki) are: Compound 24b DA NE SER racemic 35.9 1.9 8.5 (+) 17.5 1.1 5.5 (-) 775 261 537 As can be seen, most of the activity resides in a single optical antipode (or enantiomer). Hence, there is a good eudysmic ratio.
SAR For related agents, see: JNJ-7925476, McN-4612, McN-5292, McN-5558, McN5652, and McN-5908.
Other examples of drugs with ortho-chlorophenyl rings include: Ketamine Clofedanol Clortermine Tulobuterol Disobutamide Bidisomide
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