Onésiphore is a French masculine given name. Notable people with the given name include:
Onésiphore Carbonneau (1852–1932), Canadian politician Onésiphore Ernest Talbot (1854–1934), Canadian politician Onésiphore Turgeon (1849–1944), Canadian politician Onésiphore Pecqueur (1792–1852), French mechanical engineer Édouard-Onésiphore Martin (1841–1889), Canadian politician