Rafanelli () or Raffanelli () is an Italian surname. It comes from the medieval name Rafano. Notable people with the surname include:
(born 1978), Italian TV host Ivo Raffanelli or Rafanelli (born 1965), Croatian naval officer Leda Rafanelli (1880–1971), Italian author Sarah Rafanelli (born 1972), American association football player Rinaldo Rafanelli (1949–2021), Argentine bassist
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