Didelphodus is an extinct genus of eutherian mammal that inhabited North America and Europe during the Eocene epoch. It was insectivorous.

Taxonomy The genus Didelphodus was erected by E. D. Cope in 1882, with the type species Deltatherium absarokae transferred to his new genus. The genus has been placed in the family Leptictidae or in the family Cimolestidae.

Species placed in the genus include: Didelphodus absarokae (Cope, 1881) (type species) Didelphodus caloris Gingerich, Folie & Smith, 2023 Didelphodus rheos Storer, 1995 Didelphodus serus Storer, 1984

Palaeoecology Based on its dental morphology and enamel δ18O values, Didelphodus had an insectivorous diet.

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