The 5th Mississippi Legislature met in Columbia, Mississippi in two sessions: first from November 5, 1821, to November 24, 1821, and then a special session from June 3, 1822, to June 30, 1822.

Senate In the first session, Lieutenant Governor James Patton served ex officio as President of the Senate. For the 1822 session, new lieutenant governor David Dickson replaced Patton. County District SenatorAdamsJoseph SessionsSamuel ClementAmiteThomas TorrenceWilkinsonJohn Joor (1st session)Abram M. Scott (2nd session)Warren, ClaiborneRalph ReganPike, MarionWilliam SpencerJackson, Hancock, Green, PerryIsaac R. NicholsonLawrenceThomas AndersonJefferson, HindsJohn Turnbull (1st session)Samuel Cavit (2nd session)Monroe, Wayne, LawrenceHarman A. Hays

House Cowles Mead was unanimously elected Speaker of the House. Peter A. Vandorn was elected Clerk and James R. Whitney was elected Door-keeper; both were non-representatives. At the start of the second session, William Yerby was elected Speaker on the first day (June 3, 1822) due to Mead's absence, but resigned the following day after Mead arrived in Columbia. County RepresentativeAdamsAbram DefranceJames S. MorrowAdams (Natchez)Edward TurnerAmiteWilliam GardnerJames JonesJohn LowreyClaiborneHenry G. JohnstonAmos WhitingCovingtonGowen HarrisFranklinBailey E. ChaineyThomas CottonGreene?HancockNoel JourdanJacksonThomas BilboJeffersonCowles MeadRobert McCrayLawrenceHarmon RunnelsBrewster H. JayneJoseph CooperMarionCharles StovallMonroeWilliam CookPerryJ. J. H. MorrisPikeWiley P. HarrisWilliam DicksonJames Y. McNabbWarrenJacob HylandWayneSamuel W. DicksonJosiah WattsWilkinsonMoses LiddellAbram M. ScottWilliam Yerby

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