The Secretary of the Presidency of Uruguay () is a government office within the Uruguayan presidency tasked with overseeing the government's general administration and assisting the President of the Republic in their functions, in addition to certain responsibilities that depend on the administration.

The Secretary of the Presidency is a political appointee of the president of the Uruguay who does not require parliamentary confirmation, and who serves at the pleasure of the President. The position was introduced in the 1967 Constitution, which establishes that the office holder acts as such in the sessions of the Council of Ministers, and that he would cease to hold office once the president's term ended.

Role The responsibilities of the secretary of the Presidency are both managerial and advisory and may include the following:

Advise the Presidency of the Republic on the implementation of State policies. Plan and order the implementation and execution of all policies determined by the Presidency of the Republic. Advise the Executive Branch of the government in emergency situations. Carry out the activities or tasks entrusted to it by the President of the Republic. Organize, direct and coordinate the National Quality Program in the production of goods and services in the country.

List of Secretaries of the Presidency NameTerm of officeTenure lengthPresidentNotesStart of termEnd of term1Héctor GiorgiMarch 1, 1967March 26, 1971Óscar Diego Gestido2Carlos PiránMarch 26, 1971February 28, 1972Jorge Pacheco Areco3Luis Barrios TassanoMarch 1, 1972June 27, 1973Juan María Bordaberry4Álvaro Pacheco SeréJune 27, 1973August 31, 19765Luis Vargas GarmendiaSeptember 1, 1976March 1, 1980Aparicio Méndez6Enrique FerriMarch 1, 1980August 31 , 19817Ángel Mario ScelzaSeptember 1, 1981February 12 , 1985Gregorio Conrado Álvarez8Miguel SeminoMarch 1, 1985November 30, 1989Julio María Sanguinetti9Carlos BalsaNovember 30, 1989March 1, 1990Carlos Balsa10Pablo García PintosMarch 1, 1990March 1, 1995Luis Alberto Lacalle11Elías BluthMarch 1, 1995February 29, 2000Julio María Sanguinetti12Raúl Lago FinsterwaldMarch 1, 2000February 28, 2005Jorge Batlle13Gonzalo FernándezMarch 1, 2005March 3, 2008Tabaré Vázquez14Miguel Toma SanchisMarch 3, 2008February 28, 201015Alberto Breccia GuzzoMarch 1, 2010October 31, 2012José Mujica16Homero GuerreroNovember 1, 2012February 28, 201517Miguel Toma SanchisMarch 1, 2015February 28, 2020Tabaré Vázquez18Álvaro Delgado CerettaMarch 1, 2020December 21, 2023Luis Lacalle Pou19Rodrigo FerrésDecember 21, 2023March 1, 202520Alejandro SánchezMarch 1, 2025 Incumbent Yamandú Orsi

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