Oesterle is a surname. Notable people with the surname include:
Bill Oesterle (1965–2023), American venture capitalist Heather Oesterle (born 1979), American basketball player and coach Joseph Oesterlé (born 1954), French mathematician Jordan Oesterle (born 1992), American ice hockey player Jutta Oesterle-Schwerin (born 1941), German politician Michael Oesterle (born 1968), German-born Canadian composer Nathalie Colin-Oesterlé (born 1965), French lawyer and politician