Kupffer is a surname. Notable people with the surname include: Adolph Theodor Kupffer (1799–1865), German chemist and physicist Elisar von Kupffer (1872–1942), German artist, anthologist, poet, historian, translator and playwright Hugo von Kupffer (1853–1928), German journalist and writer Karl Wilhelm von Kupffer (1829–1902), German anatomist, who discovered stellate macrophage cells that bear his name, Kupffer cell Xenja von Ertzdorff-Kupffer (1933–2013), German medievalist and philologist