Nayo is both a given name and a surname. Notable people with the name include:
Nayo Raincock-Ekunwe (born 1991), Canadian basketball player Nayo Wallace, American actress Afi Nayo (born 1969), French artist Alice Nayo (born 1993), French basketball player Christopher Kwaku Nayo (1926–2003), Ghanaian politician N. Z. Nayo (1922–1993), Ghanaian academic Gaëlle Nayo-Ketchanke (born 1988), French weightlifter