The twenty-first season of American Dad! premiered on TBS on October 28, 2024, and ended on March 24, 2025. The season featured guest appearances from Kevin Bacon, Charles Barkley, Bret Hart, Gabriel Iglesias, Michael Imperioli, Leslie Jones, Neal McDonough, Joel McHale, and Kyra Sedgwick. The series focuses on the eccentric upper middle class Smith family in a fictionalized version of Langley, Virginia and their eight housemates: Father, husband, CIA agent, and Republican, Stan; his wife and housewife, Francine; their liberal, hippie, college-aged daughter, Hayley-Fischer; their dorky high-school-aged son, Steve; the family's unusual goldfish, Klaus; flamboyant, master of disguise alien, Roger; Jeff Fischer, Hayley Smith's stoner husband who resides with the Smith family; And Roger's ex-tumor son Rogu. Season 21 aired weekly without breaks throughout October 2024 to March 2025.
It was the tenth and final season to premiere on TBS, as it was announced that the series would return to its original network, Fox, on February 22, 2026.
It would also be the final season to use the opening sequence since Season 5, as a new opening sequence would debut the following season.
Voice cast and characters
Regular Seth MacFarlane as Stan Smith, Roger Smith, Greg Corbin Wendy Schaal as Francine Smith Scott Grimes as Steve Smith Rachael MacFarlane as Hayley Smith Dee Bradley Baker as Klaus Heisler, Rogu Jeff Fischer as Jeff Fischer
Supporting characters Patrick Stewart as Avery Bullock Kevin Michael Richardson as Principal Brian Lewis Curtis Armstrong as Schmuley "Snot" Lonstein Daisuke Suzuki as Toshi Yoshida Eddie Kaye Thomas as Barry Robinson Rachel Dratch as Nerfer Nicole Shabtai as Danuta Tenuta Alan Tudyk as Dr. Kalgary Nicole Shabtai as Esther Lonstein
Production The episode "Guardian" was written originally as the series finale due to the series' cancellation from TBS, similarly to Season 8's "Hot Water" and Season 19's "Echoes".
On March 21, 2025, it was announced that this would be the final season to premiere on TBS. The series will continue to air reruns on the network alongside sister channels Adult Swim and TruTV until 2030. Beginning with season 22, the series will return to Fox for new episodes.
This season is Ron Hughart's last in his role of supervising director, which he had held from the first episode. Hughart retired from animation following the end of the season's production.
20th anniversary The series' 20th anniversary celebration began with the release of the soundtrack album "American Dad! Greatest Hits" and featured 19 original songs from the show's history including "Good Morning USA", "We're Red & We're Gay", "Girl, You Need a Shot (of B12)", "Ollie North", "Zooka Sharks Rap" and a remastered version of the song from the episode Hot Water, "Daddy's Gone". It was released on October 25, 2024 ahead of the 21st season premiere. Additionally, the episode "Get Him to the Greek Lifestyle" aired on the show's 20th anniversary.
Episodes
References
External links