Samuel L. may refer to:
Samuel L. Jackson (born 1948), American actor Samuel L. Clemens aka Mark Twain (1835–1910), American author Samuel L. Devine (1915–1997), American politician Samuel L. Gravely Jr. (1922–2004) African-American naval officer Samuel L. Greitzer (1905–1988), American mathematician Samuel L. Lewis (1896–1971) American mystic and horticulturalist Samuel L. Mitchill (1764–1831) American physician, naturalist, and politician Samuel L. Popkin (born 1942), American political scientist Samuel L. Southard (1787–1842), American statesman