Onofri is an Italian surname derived from the given name Onofrio. Notable people with the surname include:
Antonio Onofri (1759–1825), Sammarinese politician and diplomat Crescenzio Onofri (1634–1712/14), Italian painter Enrico Onofri (born 1967), Italian violinist and conductor Tommaso Onofri (2004–2006), Italian murder victim Vincenzo Onofri (), Italian sculptor
See also D'Onofrio Onofrio