Tambwe is a surname. Notable people with the surname include:
Amissi Tambwe (born 1988), Burundian footballer Aristot Tambwe-Kasengele (born 2004), Congolese footballer Madosh Tambwe (born 1997), South African rugby player Patiyo Tambwe (born 1984), Congolese footballer Patrick Tambwé (born 1975), Congolese-born French long-distance runner Saidi Tambwe (born 1952), Tanzanian footballer