Mühlen is a German surname. Notable people with the surname include:
Ernest Mühlen (1926–2014), Luxembourgish politician Georg Mühlen-Schulte (1882–1981), German writer Heribert Mühlen (1927–2006), German theologian Hermynia Zur Mühlen (1883–1951), Austrian writer and translator Kurt von Mühlen (1905–1971), German military officer Louis Muhlen-Schulte (born 1998), Australian alpine skier Raimund von zur-Mühlen (1854–1931), German tenor Tomo in der Mühlen, German musician
See also Mühlen, municipality in Styria, Austria