Akuoko is a Ghanaian surname. Notable people with the surname include:
AJ Akuoko-Sarpong (born 1991), Ghanaian media personality Ebenezer Augustus Kwasi Akuoko (1928–2021), Ghanaian lawyer and politician Emmanuel Akuoko (born 1983), Ghanaian footballer Nana Akuoko Sarpong (born 1938), Ghanaian traditional ruler and politician Richard Akuoko Adiyiah (1955–2022), Ghanaian politician