Chromosome 13 open reading frame 16 is a protein in homo sapiens encoded by the C13orf16 gene. There is one alias name, TEX29, for the high testis expression of this gene due to spermatogenesis.
C13orf16 in Homo sapiens is located on the long arm of chromosome 13 at q34. The spliced gene is 859 nucleotides, has 7 exons and is located on the plus strand.
C13orf16 is ubiquitously expressed among human tissues, with significantly higher expression in brain tissues, specifically in the hippocampus and cerebellum.
Protein The human C13orf16 protein encoded by the mRNA sequence is 174 amino acids in length. The molecular weight without post-transitional modifications is 18.4 KD and the basal isoelectric point value is 4.99 pH.
Human C13orf16 is localized both intracellularly, in the nucleus, and extracellularly with one transmembrane domain from amino acids 80-102. There are no asparagines, resulting in no N-glycosylation sites.
There are five interacting proteins for human C13orf16, all identified by physical interactions.
+ Interacting proteins for human C13orf16 protein Abbreviated Name Full Name Brief DescriptionPTS6-Pyruvoyltetrahydropterin SynthaseElimination of inorganic triphosphate from dihydroneopterin triphosphate
(2nd and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP)SLC16A2Solute Carrier Family 16 Member 2Non-redundant, thyroid hormone transporterSTEAP3STEAP Family Member 3, MetalloreductaseIron transporter, can reduce both iron (Fe3+) and copper (Cu2+) cationsSLC4A7Solute Carrier Family 4 Member 7Sodium bicarbonate cotransporter, transports sodium and bicarbonate ions in a 1:1 ratio, considered an electroneutral cotransporterSLC6A15Solute Carrier Family 6 Member 15Neutral amino acid transporter, predicted to play a role in neuronal amino acid transport
Homology and evolution
The C13orf16 protein was only found to have orthologs in placental mammals and most distantly found in the Proboscidea taxonomic group. In the table below, orthologs are sorted first by estimated date of divergence, then by sequence identity to the human C13orf16 protein. + Orthologs of human C13orf16 proteinGenus & SpeciesCommon NameTaxonomic GroupDate of Divergence (MYA)Accession NumberSequence Length (aa)Sequence Identity to Human ProteinSequence Similarity to Human ProteinHomo sapiensHumanPrimates0NP_001290062174100%100%Nomascus leucogenysNorthern GibbonPrimates19.5XP_01236242617391%94.80%Macaca mulattaRhesus MacaquePrimates28.8XP_02869317218244.30%51.70%Cebus imitatorWhite-faced CapuchinPrimates43XP_03758534117970.60%77.80%Peromyscus maniculatus bairdiiDeer MouseRodentia87XP_04211868517627.20%38.60%Peromyscus leucopusWhite-Footed MouseRodentia87XP_03706748317626.70%38.60%Oryctolagus cuniculusEuropean RabbitLagomorpha87XP_05168563014325.80%30.80%Phoca vitulinaHarbor SealCarnivora94XP_03225841516234%43.50%Neofelis nebulosaClouded LeopardCarnivora94XP_05859854516534.00%45.20%Phacochoerus africanusWarthogArtiodactyla94XP_04761227317132.10%41.80%Balaenoptera riceiRice's WhaleArtiodactyla94XP_05975922914729.30%36.40%Hyaena hyaenaStriped HyenaCarnivora94XP_03908261515129.00%39.40%Ailuropoda melanoleucaGiant PandaCarnivora94XP_03452138014725%31.20%Hippopotamus amphibius kibokoEast African HippoArtiodactyla94XP_05756379314723.70%34.30%Artibeus jamaicensisJamaican Fruit BatChiroptera94XP_036993559.214921.70%30.40%Vulpes lagopusArctic FoxCarnivora94XP_04158676717821.7%%30.0%%Equus caballusHorsePerissodactyla94XP_00560139813620.80%27.00%Talpa occidentalisSpanish MoleTalpidae94XP_03738340616219.30%25.00%Diceros bicornis minorBlack RhinoPerissodactyla94XP_05840371818118.80%24%Elephas maximus indicusIndian ElephantProboscidea99XP_04972347614523.80%35.10%
References