Chromosome 17 Open Reading Frame 107 is a protein encoded by the C17orf107 gene in Homo sapiens. C17orf107 in located intracellularly with a secondary structure of five alpha helixes.
Gene
Location
Human C17orf107 is located on the short arm of chromosome 17 at p 13.2. With introns, the gene spans nucleotides 4,899,536 to 4,906,715. The spliced gene is 3,201 nucleotides with three exons on the plus strand.
Gene Level Regulation Human C17orf107 is expressed ubiquitously in tissues with the heart and brain tissues having a higher expression and the endocrine and salivary gland tissues having the highest expression.
Protein
Human C17orf107 protein, encoded by the mRNA sequence, is 190 amino acids in length. The molecular mass of the protein is approximately 20 kDa with a basal isoelectric point of 7 pH. C17orf107 is a part of the DUFF5536 conserved protein domain which is part of the pfam17688, a member of the superfamily cl39220.
Protein Level Regulation Human C17orf107 protein is localized intracellularly with no transmembrane domains. There is evidence of being expressed in the nucleoplasm. The protein has no asparagines, therefore there are no N-glycosylation sites. C17orf107 protein does not have post-translational modifications, disulfide bonds, or signal peptides.
Evolution
Orthologs
Human C17orf107 is found in all mammals except Monotremes, Hyracoidea, Tubulidentata, Cingulata, Peramelemorphia, Paucituberculata, Sirenia, and Notoryctemorphia groups. The C17orf107 gene first appeared in mammals with the earliest found species dating back to 160 million years ago in marsupials. The table below shows protein orthologs to Human C17orf107, sorted by estimated date of divergence, then by taxonomic group, and lastly sequence identity scores.
+ Orthologs Taxonomic group Common name Genus and species Accession number Date of Divergence (MYA) Sequence length (aa) Sequence identity (%) ! !Sequence similarity (%) Sequence Gaps (%) Primates Human Homo sapiens NP_001139008.1 — 190 — — — Western Lowland Gorilla Gorilla gorilla gorilla XP_018868465.1 9 189 82 83 15 Lagomorpha European Rabbit Oryctolagus cuniculus XP_008269053.1 87 204 64 72 13 Rodentia House Mouse Mus musculus EDL12584.1 87 128 33 37 55 Artiodactyla East African Hippopotamus Hippopotamus amphibius kiboko XP_057569928.1 94 183 78 84 4 Sheep Ovis aries KAG5203555.1 94 233 51 55 34 Wild Bactrian Camel Camelus ferus EPY72335.1 94 183 43 50 32 Carnivora Sea Otter Enhydra lutris kenyoni XP_022380488.1 94 216 63 69 19 Giant Panda Ailuropoda melanoleuca XP_034502549.1 94 247 58 63 25 Clouded Leopard Neofelis nebulosa XP_058561310.1 94 90 40 44 53 Cetacea Harbor Porpoise Phocoena phocoena XP_065753064.1 94 179 70 79 11 Narwhal Monodon monoceros TKC42450.1 94 263 26 30 51 Chiroptera Nathusius Pipistrelle Bat Pipistrellus nathusii CAK6437783.1 94 135 39 45 42 Perissodactyla Horse Equus caballus XP_005597777.1 94 212 69 75 16 Southern White Rhinoceros Diceros bicornis minor XP_058415933.1 94 218 67 75 13 Pholidota Sunda Pangolin Manis javanica XP_017503787.1 94 197 65 73 8 Proboscidea Indian Elephant Elephas maximus indicus XP_049717565.1 99 248 56 62 26 Marsupial Agile Gracile Opossum Gracilinanus agilis XP_044529018.1 160 179 50 52 22 Tasmanian Devil Sarcophilus harrisii XP_012404229.1 160 189 48 59 22 Monito Del Monte Dromiciops gliroides XP_043856787.1 160 198 41 52 20
References