Meddeb is a French surname. Notable people with the surname include:
Abdelwahab Meddeb (1946–2014), French–Tunisian writer, critic and academic Hamdi Meddeb (born 1952), Tunisian Hind Meddeb (born 1978), French–Tunisian film producer and journalist Mohamed Meddeb (born 1981), Tunisian shot putter Moncef Meddeb (died 2019), American chef Rached Meddeb (born 1940), Tunisian footballer