Calvillo is a surname. Notable people with the surname include:
Anthony Calvillo (born 1972), American coach and former player of Canadian football Cynthia Calvillo (born 1987), American mixed martial artist Eric Calvillo (born 1998), American born soccer player María del Carmen Calvillo (1765–1856), rancher in Spanish Texas Nerea Calvillo (born 1973), Spanish architect and researcher
See also Calvillo, a city in Aguascalientes, Mexico