The Santa Clara–Caibarién Road (4–321), also known as the Road of Camajuaní, is a Cuban state highway connecting the cities of Santa Clara to Caibarién. It starts at a roundabout with the Avenida Liberacion and the Santa Clara Beltway in Santa Clara, to continue east through the settlements of Minagric, Los Moros, La Granjita, El Gigante, the University of Las Villas, Camilo Cienfuegos, Los Güiros, Los Paragüitas, El Amparo, El Berro, Crucero Carmita, Blanquizal, Tarafa, Monte de la Coja, Camajuaní, El Níspero, Entronque de Vueltas, Muelas Quietas, Taguayabón, Aguanó, El Chalet, Remedios, Marcelo Salado, and finally reaches Caibarién.

History

In the 1960s, the roadway was known as the 4–21.

In June 2024, in Crucero Carmita on the 4–321, a tourist Transgaviota bus, coming from Cayo Santa María to the Abel Santamaría Airport, and a privately owned car crashed into each other, with 26 injuries and 1 death, with it being suggested the car went into the left lane, which is common in the region.

Also in June 2024, residents living nearby the road, in the Santa Clara-Camajuani area, protests and blocked the road due to lack of drinking water in the region for 50 days. Residents have been seen getting buckets of water going along the road in order to have drinking water. Sources say over 3,500 people living in neighborhoods around the road have been affected in an over 68 day period.

Route

MunicipalityLocationkmmiDestinationNotesSanta ClaraSanta Clara00 Santa Clara Beltway / To 4–N–1 (Carretera Central) / To 4–311 (Carretera de Maleza)Continues onto Avenida Liberacion2.28Textilera Texvi2.99Ciudad Escolar Che Guevara4.32Calle Lazaro Cardenas – Lazaro Cardenas School4.83 4–431 (Calle 5ta)5.35University of Las Villas entrance6.22University of Las Villas sports section6.29University of Las Villas agriculture facilities6.52Alley of Los Patos – Callejon de los Patos, Camilo CienfuegosLos Guiros9.11Calle 1ra – Crucero MargotEl Amparo12.86PLOMAC14.96Road to Cayo Santa María – Abel Santamaría Airport, Encrucijada15.96Salaminas Matadero AlamoEl Berro16.28Campismo Minerva, Embalse MinervaSanta Clara-Camajuaní border17.04Sagua la Chica River BridgeCamajuaníCrucero Carmita17.65Road to Luis Arcos Bergnes – Luis Arcos Bergnes, Vega Alta#1343 train tourist attraction located at junctionSanta Fe19.88Santa Fe Curve20.49Road of Corona – Corona22.85Camajuaní River BridgeCamajuaní24.58La Quinta Road – El Bosque, La Quinta25.42 4–401 (Calle General Naya / Carretera al Fe)  – Arroyo Frio, José María Pérez, Sabana, Placetas26.13Calle Leoncio VidalEntronque de Vueltas29.32 4–I–3 (Circuito Norte) – Vega de Palma, Vueltas, Aguada de MoyaWestern terminus of concurrency with the 4–I–3Taguayabón33.12Calle José Rivadeneira Blanco36.20Palenque Heights36.72PalenqueRemedios39.08Martires de Angola SchoolRemedios42.37Circunvalación de Remedios43.53 4–461 (Carretera a Zulueta) – Zulueta, Placetas44.22Calle Enrique Malaret – Jinaguayabo, Playa Jinaguayabo44.22 4–511 (Calle Camilo Cienfuegos / Carretera a Rojas) – Rojas, Guajabana44.62Avenida Marcelo Salado45.18Circunvalación de RemediosDolphin fountain tourist attraction46.20Remedios 110kv, Batería Grupo Electrógeno RemediosCaibarién47.8547.89Curva de WaterlooCaibarién49.43Calle F49.65Calle 9 / Calle A / Calle 849.90Calle 450.18Calle 150.50Caibarien Remedios Road51.82Calle 4251.94Calle 5ta / Calle 4052.3332.52 4–I–3 (Circuito Norte / Calle 34) / Avenida 9Eastern terminus of concurrency with the 4–I–3; Continues as Avenida 11

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