Von Uexküll is a surname. Notable people with the surname include:
Alexander Rudolf Karl von Uexküll (1829–1891), Baltic German politician (1864–1923), Russian-German philosopher (1630–1701), Baltic German politician (1762–1827), Estonian knight and politician Berend Johann Friedrich von Uexküll (1793–1870), known as "Boris Uxkull", Baltic soldier, traveller and diarist Carl Wolmar Jakob von Uexküll (born 1944) Swedish-German writer, lecturer, philanthropist, activist and politician (1668–1710), Baltic German landowner and politician (1909–1993), German screenwriter and journalist (1925–2005), Estonian agricultural scientist Johann von Uexküll (died 1583), Baltic German noble and politician
Jakob Johann von Uexküll (1864–1944), Baltic German biologist, zoologist and philosopher (1569–1638), Estonian Army officer and landowner (died 1601), Swedish field marshal (died 1545), Estonian landlord , Estonian landowner