The 1980 Bethune–Cookman Wildcats football team represented Bethune–Cookman College (now known as Bethune–Cookman University) as a member of the Mid-Eastern Athletic Conference (MEAC) during the 1980 NCAA Division I-AA football season. Led by second-year head coach Bobby Frazier, the Wildcats compiled an overall record of 6–3–1, with a mark of 2–2–1 in conference play, and finished tied for third in the MEAC.

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