Karmele is a Basque feminine given name. People with the name include:
Karmele Jaio (born 1970), Spanish writer and journalist Karmele Leizaola (1929–2021), Basque-born Venezuelan graphic designer Karmele Makazaga (born 1964), Spanish team handball player Karmele Marchante (born 1946), Spanish journalist and feminist Miren Karmele Azkarate Villar (born 1955), Spanish politician, professor of Basque philology