Francesco Zaffini (born 9 March 1955) is an Italian politician of Brothers of Italy serving as a member of the Senate of the Republic. He was first elected in the 2018 general election, and was re-elected in 2022. Since 2022, he has chaired the Social Affairs and Health Committee.

Zaffini previously served as a member of the Legislative Assembly of Umbria from 2005 to 2015.

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