2-Chloronicotinic acid (2-CNA) is a halogenated derivative of nicotinic acid.
Synthesis It can be synthesized by chlorination of the N-oxide of nicotinic acid or the related nicotinonitrile. Alternatively, it has been prepared by substitution of the hydroxyl group of 2-hydroxynicotinic acid or by a tandem reaction involving cyclization of various acrolein derivatives.leading references: Applications 2-Chloronicotinic acid is an intermediate in the production of a variety of bioactive compounds, including boscalid and diflufenican.
Other reported uses include Propizepine,Hoffmann, Faure, Bull. Soc. Chim. Fr. 1966, 2316. Amdiglurax, Morniflumate, Niflumic acid, nevirapine, Clonixeril, and Flunixin.
References