Mkhwanazi is a South African surname. Notable people with the surname include:
Buhle Mkhwanazi (born 1990), South African footballer David Mkhwanazi (born 1951), South African politician Jabulile Mkhwanazi (born 1975), South African politician Julius Mkhwanazi (born 1973), South African law enforcement official Lindokuhle Mkhwanazi (born 1985), South African footballer Nhlanhla Mkhwanazi (born 1973), South African law enforcement officer Sinamile Mkhwanazi (born 2004), South African soccer player Zibusiso Mkhwanazi (born 1983), South African businessman