2C-T-21.5, also known as 4-(2,2-difluoroethylthio)-2,5-dimethoxyphenethylamine or as 2C-T-DFE, is a lesser-known psychedelic drug related to compounds such as 2C-T-21 and 2C-T-28. It was originally named by Alexander Shulgin and discussed in his book PiHKAL (Phenethylamines I Have Known and Loved), but was not synthesised at that time. 2C-T-21.5 was ultimately synthesised and tested by Daniel Trachsel some years later. It has a binding affinity of 146 nM at 5-HT2A and 55 nM at 5-HT2C. It produces typical psychedelic effects, being slightly less potent but somewhat longer acting than 2C-T-2 or 2C-T-21, with an active dose of 12–30 mg, and a duration of action of 8–14 hours. Unlike 2C-T-21 it will not form the highly toxic fluoroacetate as a metabolite, instead producing the less toxic difluoroacetic acid. It is a controlled substance in Canada under phenethylamine blanket-ban language.
See also 2C (psychedelics) 2C-T-22 2C-T-16 2C-T-35 2C-T-TFM 2C-TFE 3C-DFE DOPF Trifluoromescaline 2C-x DOx 25-NB
References
External links 2C-T-21.5 - Isomer Design