Heleophryne is a genus of ghost frogs. They are known from mountainous regions of South Africa, Lesotho, and Eswatini.

One member of the genus, the Table Mountain ghost frog (H. rosei) is considered an EDGE species.

Species The following species are classified in this genus: Cederberg ghost frog (Heleophryne depressa) FitzSimons, 1946 Hewitt's ghost frog (Heleophryne hewitti) Boycott, 1988 Eastern ghost frog (Heleophryne orientalis) FitzSimons, 1946 Purcell's ghost frog (Heleophryne purcelli) Sclater, 1898 Royal ghost frog (Heleophryne regis) Hewitt, 1910 Rose's ghost frog (Heleophryne rosei) Hewitt, 1925

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