Amoussou is a surname. Notable people with the surname include:
Bertrand Amoussou-Guenou (born 1966), French mixed martial artist Bruno Amoussou (born 1939), Beninese politician Jean Paul Amoussou (born 1970), Beninese actor Karl Amoussou (born 1985), French-German mixed martial artist Ralph Amoussou (born 1989), French actor Sylvestre Amoussou (born 1964), Beninese actor Valère Amoussou (born 1987), Beninese footballer