Najafov is a surname. Notable people with the surname include:
Fakhraddin Najafov (1967–1992), National Hero of Azerbaijan Fariz Najafov (born 1978), Azerbaijani karateka Fazil Najafov (1935–2023), Azerbaijani artist Huseyn Najafov (1907–1967), Azerbaijani politician Khayal Najafov (born 1997), Azerbaijani footballer Yunis Najafov (1967–1992), National Hero of Azerbaijan