Frederick Holmes may refer to:
Frederick Holmes (athlete) (1886–1944), British Olympic tug of war competitor Frederick William Holmes (1889–1969), British Army officer and Victoria Cross recipient Frederick Hale Holmes (1812–1875), professor of chemistry and pioneer of electric lighting Frederick S. Holmes (1865–1948), American safe and vault engineer Fred Holmes (Frederick Clarence Holmes, 1878–1956), Major League Baseball player
See also Frederic L. Holmes (1932–2003), American historian of science