Plaatjies is a surname. Notable people with the surname include:
Asisipho Plaatjies (born1996), South African rugby player Dizu Plaatjies (born 1959), Xhosa musician Francois Plaatjies (born 1986), South African cricketer Mary-Anne Plaatjies van Huffel (1959–2020), South African pastor Sydney Plaatjies (born 1981), Namibian footballer