Syamsuddin is an Indonesian name. Notable people with the name include:
Syamsuddin Mahmud (1935–2021), Indonesian politician Syamsuddin Umar (born 1955), Indonesian football manager Amir Syamsuddin (born 1941), Indonesian politician Azis Syamsuddin (born 1970), Indonesian politician Din Syamsuddin (born 1958), Indonesian politician Syaiful Syamsuddin (born 1993), Indonesian footballer