Walusimbi is a surname. Notable people with the surname include:
Enock Walusimbi (born 1998), Ugandan footballer Godfrey Walusimbi (born 1989), Ugandan footballer John Baptist Walusimbi, Ugandan politician and engineer Samuel Walusimbi (born 1948), Ugandan cricketer Sarah Walusimbi, Ugandan lawyer Solomon Walusimbi (born 1999), Ugandan footballer