Mugerwa is a surname. Notable people with the surname include:

Peter James Nkambo Mugerwa (1933–2020), Ugandan lawyer Phina Mugerwa, Ugandan singer Roy Mugerwa (1942–2019), Ugandan physician Wilberforce Kisamba Mugerwa (1945–2021), Ugandan economist Yasser Mugerwa, Ugandan footballer