Mthokozisi is a masculine given name. Notable people with the name include:
Mthokozisi Dube (born 1992), South African footballer Mthokozisi Selby Khumalo (born 1971), South African politician, civil servant and preacher Malachi Tyrese Mthokozisi Napa (born 1999), English footballer Mthokozisi Nxumalo (1989–2021), South African politician Mthokozisi Shezi (born 1987), South African cricketer and umpire Mthokozisi Yende (born 1984), South African footballer