Serasinghe is a surname. Notable people with the surname include:
Herbert Clifford Serasinghe, Ceylonese physician Iranganie Serasinghe (born 1927), Sri Lankan actress Pushpakumara Serasinghe (born 1963), Sri Lankan cricketer Sachithra Serasinghe (born 1987), Sri Lankan cricketer Sawan Serasinghe (born 1994), Australian badminton player