Premachandra () is a Sinhalese surname. Notable people with the surname include:
Anuki Premachandra, Sri Lankan social activist Appunidage Premachandra (born 1953), Sri Lankan sprinter Bharatha Lakshman Premachandra (1955–2011), Sri Lankan politician Dandeniya Premachandra de Silva, Ceylonese cricketer Gihan Premachandra (born 1980), Sri Lankan cricketer G. M. Premachandra (1940–1994), Sri Lanka politician Hirunika Premachandra (born 1987), Sri Lankan politician H. R. U. Premachandra (1910), Ceylonese politician P. B. Premachandra (born 1957), Sri Lankan Air Force officer Sumudu Premachandra, Sri Lankan judge of the Court of Appeal