Karunanayake is a surname. Notable people with the surname include:
Kamal Karunanayake (1937–2006), Sri Lankan politician Lakmali Karunanayake, Sri Lankan judge of the Court of Appeal Nipun Karunanayake (born 1991), Sri Lankan cricketer Ravi Karunanayake (born 1963), Sri Lankan politician Shalika Karunanayake (born 1987), Sri Lankan cricketer