Jayasekera is a surname. Notable people with the surname include:
D. S. Jayasekera (), Sri Lankan teacher Kingsley Jayasekera (1924–2004), Sri Lankan actor Lakkana Jayasekera (born 1996), Sri Lankan cricketer Michael Jayasekera (), Sri Lankan rugby union player Nicholas Jayasekera (), Sri Lankan rear admiral Rohan Jayasekera (cricketer) (born 1957), Sri Lankan cricketer Rohan Jayasekera (writer) (born 1961), English freelance journalist Shantha Jayasekera (born 1963), Sri Lankan cricketer Thushari Jayasekera (born 1984), Sri Lankan-American actress