Karunasena is both a given name and a surname. Notable people with the name include:
Karunasena Jayalath (1928–1994), Sri Lankan newspaper editor Karunasena Kodituwakku (born 1945), Sri Lankan politician Ruchira Karunasena (born 1977), Sri Lankan cricketer W. A. Karunasena (born 1928), Ceylonese politician