Gunatilleke is a surname. Notable people with the surname include:
C. V. Savitri Gunatilleke (born 1945), Sri Lankan academic Damith Gunatilleke (born 1983), Sri Lankan cricketer Kantha Gunatilleke, Sri Lankan politician Ranjan Gunatilleke (born 1951), Sri Lankan cricketer Thanura Gunatilleke (born 1977), Sri Lankan cricketer V. C. Gunatilleke, Sri Lankan politician