Dissanaike (Sinhala: දිසානායක) is a Sinhalese family name. It is one romanization of දිසානායක, the most common romanization being "Dissanayake". Notable people with the family name include:
George Dissanaike (1927–2008), Sri Lankan academic Gishan Dissanaike, British Sri Lankan economist Senesh Dissanaike Bandara, Sri Lankan film director Stanley Dissanaike (1925-2015), Sri Lankan parasitologist