Leucine rich repeat containing 27 (LRRC27) a is a protein which in humans is encoded by the LRRC27 gene.
Gene Homo sapiens gene Leucine Rich Repeat containing 27 (LRRC27) is a protein coding gene that is located on chromosome 10 at 10q26.3....NCBI (National Center for Biotechnology Information) Nucleotide. Homo sapiens leucine rich repeat containing 27 (LRRC27). . The gene is on the plus (+) strand, and is 8251 base pairs long. The gene has 9 exonsNCBI (National Center for Biotechnology Information) Gene. Homo sapiens leucine rich repeat containing 27 (LRRC27). https://www.ncbi.nlm.nih.gov/gene/80313
Transcript LRRC27 has 45 transcript variants. Transcript variant 2 encodes isoform a in humans. The mRNA sequence for this variant is 8251 base pairs in length,NCBI (National Center for Biotechnology Information) Nucleotide. Homo sapiens leucine rich repeat containing 27 (LRRC27). and all 9 exons are present.
The LRRC27 transcript has low and variable expression in many tissues, but with notable amounts of the transcript present in the brain, fetal brain, and testisNational Center for Biotechnology Information. GEO Profile results for LRRC27 AND GDS3113. https://www.ncbi.nlm.nih.gov/geo/tools/profileGraph.cgi?ID=GDS3113:170833Szabo, L., Morey, R., Palpant, N.J. et al. Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Genome Biol 16, 126 (2015). https://doi.org/10.1186/s13059-015-0690-5
Protein LRRC27 Isoform a in humans is 530 amino acids long with a predicted molecular weight of ~60 kDa and predicted isoelectric point around 9.Expasy. Compute pI/Mw. (https://web.expasy.org/cgi-bin/compute_pi/pi_tool.cgi ) It is relatively poor in tyrosine compared to other proteins.EMBL-EBI SAPS. Sequence Statistics. (https://www.ebi.ac.uk/jdispatcher/seqstats/saps/summary?jobId=saps-I20240722-031647-0802-84915747-p1m&js=pass ) LRRC27 is also largely localized in the nucleus of a cell.PSORT II Results for LRRC27 protein
Domains and Motifs
The protein has 5 leucine rich regions and 2 disordered regionsNational Center for Biotechnology Information (NCBI) Nucleotide results for LRRC27. https://www.ncbi.nlm.nih.gov/nuccore/NM_001143757.2
Structure LRRC27 structure is largely helical, with strands present in the leucine rich regions of the proteinPredict Protein. Secondary Structure results for LRRC27. (https://predictprotein.org/visual_results?req_id=$2y$10$Gx3aBD1BHu5Z5vq.cdU7/uOrEV216aOp5Otixb3XTdz4ugk/w6qZ2#JobRunDialogue )
Post-Translational Modifications LRRC27 has several phosphorylation, o-linked glycosylation, and sumoylation sites that may change its structure post-translationally.DTU Health Tech. Bioinformatic Services. (https://services.healthtech.dtu.dk/ )The Cuckoo Group. GPS SUMO. (https://sumo.biocuckoo.cn/showResult.php )
Evolution
Paralogs Paralogs for LRRC27 include LRRC7 (Leucine Rich Region Containing 7) and LRCH1 (Leucine Rich Repeats and Calponin Homology Domain Containing 1).GeneCards. The Human Gene Database. LRRC27 Paralogs. https://www.genecards.org/cgi-bin/carddisp.pl?gene=LRRC27#paralogs
Orthologs LRRC27 is widely conserved in mammals, and moderately conserved in certain reptiles, amphibians, fish and birds. There are no orthologs of this LRRC27 gene in invertebratesNational Center for Biotechnology Information (NCBI) Ortholog results for LRRC27. https://www.ncbi.nlm.nih.gov/gene/80313/ortholog/?scope=7742
Phylogeny/History LRRC27 and LRCH1 are neither evolving as quickly as Fibrinogen Alpha nor as slowly as Cytochrome C. LRCH1 appears to also be changing at a slower rate compared to LRRC27.
Clinical Significance Enriched LRRC27 expression is present in preeclampsia (PE). LRRC27 is overexpressed in platelets unique to PE, compared to a healthy pregnancy.
A single nucleotide polymorphism in LRRC27 is also significantly associated with the pathogenesis of primary open-angle glaucoma (POAG). Increased expression of LRRC27 with SNP rs116121322 was shown to be associated with POAG.
Another study attempting to characterize the variable responses to weight loss treatment also found that the expression of several genes, including LRRC27, were highly variable between weight loss treatment responders and non-responder groups.
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