Wickramarachchi is a surname. Notable people with the surname include:
G. P. Wickramarachchi (1889–1975) , Sri Lankan Ayurvedic practitioners Rajitha Wickramarachchi (born 1987), Sri Lankan cricketer M Y Wickramarachchi: Sri Lankan-origin Australian based entrepreneur
See also Gampaha Wickramarachchi University of Indigenous Medicine, public university located in Yakkala, Sri Lanka